Journal: BMC Research Notes

Article Title: Hereditary hearing loss SNP-microarray pilot study

doi: 10.1186/s13104-018-3466-7

Figure Lengend Snippet: Overview of data files/data sets

Article Snippet: Data set 1 , Infinium HumanOmni1-Quad v1.0 SNP-microarray data , This dataset contains the raw intensity data files (Grn.idat and Red.idat) of each patient, as well as Matrix Signal Intensities (.txt) and Matrix Processed data (.txt) , NCBI Gene Expression Omnibus Data series accession: GSE111131 Data identifiers: GSM3022603 , GSM3022604 , GSM3022605 , GSM3022606 , GSM3022607 , GSM3022608 , GSM3022609 , GSM3022610 , GSM3022611 , GSM3022612 , GSM3022613 , GSM3022614 , GSM3022615 , GSM3022616 , GSM3022617 , GSM3022618 , GSM3022619 , GSM3022620 , GSM3022621 , GSM3022622 , GSM3022623 , GSM3022624 , GSM3022625 , GSM3022626 , GSM3022627 , GSM3022628 , GSM3022629 , GSM3022630 , GSM3022631 , GSM3022632 , GSM3022633 , GSM3022634 , GSM3022635 , GSM3022636 , GSM3022637 , GSM3022638 , GSM3022639 , GSM3022640 , GSM3022641 , GSM3022642 , GSM3022643 , GSM3022644 , GSM3022645 , GSM3022646 , GSM3022647 , GSM3022648 , GSM3022649 , GSM3022650 , GSM3022651 , GSM3022652 , GSM3022653 , GSM3022654 , GSM3022655 , GSM3022656 , GSM3022657 , GSM3022658 , GSM3022659 , GSM3022660 , GSM3022661 , GSM3022662 , GSM3022663 , GSM3022664 , GSM3022665 , GSM3022666 , GSM3022667 , GSM3022668 , GSM3022669 , GSM3022670 , GSM3022671 , GSM3022672 , GSM3022673 , GSM3022674 , GSM3022675 , GSM3022676 , GSM3022677 , GSM3022678 , GSM3022680 , GSM3022681 , GSM3022682 , GSM3022683 , GSM3022684 , GSM3022685 , GSM3022686 , GSM3022687 , GSM3022688 , GSM3022689 , GSM3022690 , GSM3022691 , GSM3022692 , GSM3022693 , GSM3022694 , GSM3022695 , GSM3022696 , GSM3022697 , GSM3022698 , GSM3022699 , GSM3022700 , GSM3022701 , GSM3022702 , GSM3022703 , GSM3022704 , GSM3022705 , GSM3022706 , GSM3022707 , GSM3022708 , GSM3022709 , GSM3022710 , GSM3022711 GSE111131 _Martix_signal_intensities.txt.gz GSE111131 _Matrix_Processed.txt.gz.

Techniques: Gene Expression

Journal: Blood Cancer Journal

Article Title: Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

doi: 10.1038/s41408-022-00773-8

Figure Lengend Snippet: Summary of major studies associating L-CH with lymphoid malignancy.

Article Snippet: Niroula et al. (2021) , Detection of SNVs/indels in WES data at 56 M-CH related genes and 235 genes recurrently mutated in lymphoid malignancy (VAF > 2%). mCAs were previously detected in a prior study. CH and mCAs were excluded if they were detected less than 6 months before a hematologic malignancy diagnosis. , 420,969 individuals with SNP microarray data and 55,383 individuals with WES from the UK Biobank and Mass General Brigham Biobank , CHIP occurs at both M-CHIP/M-mCA and L-CHIP/L-mCA loci and increases with age. M-CH and L-CH loci clearly segregate on the incidence myeloid and lymphoid malignancy. M-CHIP is dominated by DNMT3A, TET2, and ASXL1 somatic mutants, while L-CHIP is spread more evenly across a large number of genes. CLL was the dominant lymphoid malignancy occurring subsequent to L-CH. , [ ] .

Techniques: Genome Wide, Sequencing, Mutagenesis, Clone Assay, Biomarker Discovery, Microarray, DNA Sequencing, Clinical Proteomics